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- W2378627539 abstract "Objective To investigate the mechanism of HSV-TK/GCV system inducing cell death of prostatic cancer cells. Methods A hormone-independent PCa cell line (PC-3m) was transfected with EBV-based expression vector containing HSV-TK gene by using liposome-mediated gene delivery technique. After administration of the GCV, the cell cycle distribution, apoptosis, and necrosis were analyzed by flow cytometry. Results There was a moderate increase in the relative number of TK-transfect-ed PC-3m cells at S phase of cell cycle following GCV treatment. The S phase blockage was more significant in the high dose group, in which the percents of the cells at S phase were elevated from 16. 73% to 33.60 % . Furthermore, analysis of apoptosis and necrosis displayed that 72 h administration of GCV triggered a rather high ratio of apoptosis and necrosis of TK gene-transduced PC-3m cells, and the magnitudes of those were 13. 54%, 12. 45 % , 34. 70 % and 10.11% respectively. Conclusion Both necrosis and apoptosis were involved in the cellular death of PC-3m cells induced by HSV-TK/GCV system. It seems that necrosis is of essential importance during the procedure. It is indicated that the killing effect of TK suicide gene approach on prostate cancer cells may independent of the background of p53 expression." @default.
- W2378627539 created "2016-06-24" @default.
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- W2378627539 date "2003-01-01" @default.
- W2378627539 modified "2023-09-23" @default.
- W2378627539 title "Flow cytometric analysis of thymidine kinase gene system inducing cell death of prostatic cancer cells" @default.
- W2378627539 hasPublicationYear "2003" @default.
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