Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378627993> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2378627993 abstract "AIM: To explore the mechanism of the nitric oxide (NO) synthesis induced by human C5b-9 complex in glomerular mesangial cells(MC) of rats. METHODS: The MC of rats were cultured and stimulated with human complement C5b-9 complex to induce TNFα and IL-1β. At the same time, several parameters related to NO synthesis were measured at 3 h, 6 h and 24 h after C5b-9 stimulation. The effects of monoclonal antibodies against TNFα and IL-1β on NO synthesis were examined in this system. RESULTS: TNFα concentration in supernatant from MC in C5b-9 group was higher than that of control group at 6, 24 h after stimulation with C5b-9 complex and reversed by adding anti-TNFα McAb. C5b-9 complex didn't stimulate the release of IL-1β in same system. In addition, the expression of iNOS mRNA in MC was observed at 3 h after stimulation with C5b-9. Levels of iNOS mRNA expression and cGMP in MC and NO - 3/NO - 2 in supernatant from MC in C5b-9 group were higher than those in control group at 6, 24 h after C5b-9 stimulation, these changes were also reversed by adding monoclonal antibody against TNFα. CONCLUSION: C5b-9 complex could induce iNOS mRNA expression at 3 h after C5b-9 stimulation, and the synthesis of NO at 6, 24 h was related to TNFα released from cultured MC of rats by C5b-9 complex to a certain extent." @default.
- W2378627993 created "2016-06-24" @default.
- W2378627993 creator A5076141593 @default.
- W2378627993 date "2001-01-01" @default.
- W2378627993 modified "2023-09-25" @default.
- W2378627993 title "Mechanisms of nitric oxide synthesis induced by human complement C5b-9complex in glomerular mesangial cells of rats" @default.
- W2378627993 hasPublicationYear "2001" @default.
- W2378627993 type Work @default.
- W2378627993 sameAs 2378627993 @default.
- W2378627993 citedByCount "0" @default.
- W2378627993 crossrefType "journal-article" @default.
- W2378627993 hasAuthorship W2378627993A5076141593 @default.
- W2378627993 hasConcept C104317684 @default.
- W2378627993 hasConcept C105580179 @default.
- W2378627993 hasConcept C111684460 @default.
- W2378627993 hasConcept C126322002 @default.
- W2378627993 hasConcept C134018914 @default.
- W2378627993 hasConcept C159654299 @default.
- W2378627993 hasConcept C17991360 @default.
- W2378627993 hasConcept C185592680 @default.
- W2378627993 hasConcept C203014093 @default.
- W2378627993 hasConcept C24998067 @default.
- W2378627993 hasConcept C2777622882 @default.
- W2378627993 hasConcept C2779131090 @default.
- W2378627993 hasConcept C2780091579 @default.
- W2378627993 hasConcept C519581460 @default.
- W2378627993 hasConcept C542903549 @default.
- W2378627993 hasConcept C55493867 @default.
- W2378627993 hasConcept C71924100 @default.
- W2378627993 hasConcept C79196540 @default.
- W2378627993 hasConcept C86803240 @default.
- W2378627993 hasConceptScore W2378627993C104317684 @default.
- W2378627993 hasConceptScore W2378627993C105580179 @default.
- W2378627993 hasConceptScore W2378627993C111684460 @default.
- W2378627993 hasConceptScore W2378627993C126322002 @default.
- W2378627993 hasConceptScore W2378627993C134018914 @default.
- W2378627993 hasConceptScore W2378627993C159654299 @default.
- W2378627993 hasConceptScore W2378627993C17991360 @default.
- W2378627993 hasConceptScore W2378627993C185592680 @default.
- W2378627993 hasConceptScore W2378627993C203014093 @default.
- W2378627993 hasConceptScore W2378627993C24998067 @default.
- W2378627993 hasConceptScore W2378627993C2777622882 @default.
- W2378627993 hasConceptScore W2378627993C2779131090 @default.
- W2378627993 hasConceptScore W2378627993C2780091579 @default.
- W2378627993 hasConceptScore W2378627993C519581460 @default.
- W2378627993 hasConceptScore W2378627993C542903549 @default.
- W2378627993 hasConceptScore W2378627993C55493867 @default.
- W2378627993 hasConceptScore W2378627993C71924100 @default.
- W2378627993 hasConceptScore W2378627993C79196540 @default.
- W2378627993 hasConceptScore W2378627993C86803240 @default.
- W2378627993 hasLocation W23786279931 @default.
- W2378627993 hasOpenAccess W2378627993 @default.
- W2378627993 hasPrimaryLocation W23786279931 @default.
- W2378627993 hasRelatedWork W1980137549 @default.
- W2378627993 hasRelatedWork W2011739933 @default.
- W2378627993 hasRelatedWork W2048126570 @default.
- W2378627993 hasRelatedWork W2089324635 @default.
- W2378627993 hasRelatedWork W2149478838 @default.
- W2378627993 hasRelatedWork W2276163512 @default.
- W2378627993 hasRelatedWork W2348833591 @default.
- W2378627993 hasRelatedWork W2374356228 @default.
- W2378627993 hasRelatedWork W2382808237 @default.
- W2378627993 hasRelatedWork W2391415288 @default.
- W2378627993 hasRelatedWork W2392815560 @default.
- W2378627993 hasRelatedWork W2392922239 @default.
- W2378627993 hasRelatedWork W2397362230 @default.
- W2378627993 hasRelatedWork W2411450523 @default.
- W2378627993 hasRelatedWork W2440626358 @default.
- W2378627993 hasRelatedWork W26325231 @default.
- W2378627993 hasRelatedWork W3030556612 @default.
- W2378627993 hasRelatedWork W3030680915 @default.
- W2378627993 hasRelatedWork W3031948358 @default.
- W2378627993 hasRelatedWork W310316625 @default.
- W2378627993 isParatext "false" @default.
- W2378627993 isRetracted "false" @default.
- W2378627993 magId "2378627993" @default.
- W2378627993 workType "article" @default.