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- W2378629245 abstract "Objectives To establish a rapid and precise detective method of 33.5 kDa vesicular protein and to screen an effective drug for cholelithiasis. Methods Specific antibody of the biliary vesicular protein was obtained by immunizing rabbits, with a view to develop an enzyme linked immunosorbent assay (ELISA) kit. The concentrations of 33.5 kDa vesicular protein in serum and bile of gallstone patients and controls were examined respectively. The effects on decreasing 33.5 kDa vesicular protein by cholagogue dry syrup and sodium cholate were also studied. Results One step ELISA provided a simple and sensitive means of measuring the biliary vesicular protein in serum and bile and its equation was Y=0.035X(r=0.99). The vesicular protein concentration in serum and bile of cholesterol gallstone group were 0.045±0.021 mg/ml and 0.050±0.010 mg/ml, respectively, significantly ( P 0.05) higher than those in the pigment stone group (0.017±0.011 mg/ml and 0.014±0.009 mg/ml, respectively) and controls ( 0.015 ±0.010 mg/ml and 0.007±0.003 mg/ml, respectively). The data showed that, when adminisered for two weeks, cholagogue dry syrup significantly decreased both biliary and serum 33.5 kDa vesicular protein in cholesterol stone patients, while sodium cholate and control groups showed no significant changes. Conclusions ELISA is a rapid and reliable method of detecting serum and biliary vesicular protein, the concentrations of 33.5 kDa vesicular protein were different in cholesterol gallstone patients and health subjects. which might be related to cholesterol nucleation process. Cholagogue dry syrup is valuable in modifying the lithogenic bile. (Shanghai Med J, 2000,23∶341 344)" @default.
- W2378629245 created "2016-06-24" @default.
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- W2378629245 date "2000-01-01" @default.
- W2378629245 modified "2023-09-24" @default.
- W2378629245 title "Establishment of an ELISA for biliary vesicular protein and its preliminary clinical study" @default.
- W2378629245 hasPublicationYear "2000" @default.
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