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- W2378629724 abstract "Objective Dendritic cells(DCs)are professional antigen-presenting cells with the ability to initiate primary T cell responses.In this study we observed the morphologic features,phenotype and function of cultured human DCs.Methods Cord blood CD34~(+) stem cells were isolated and cultured in 20% LMDM medium with SCF,GM-CSF,TGF-β_(1)、Flt-3L for 7 days,or followed by stimulating with TNF-α for additional 7 days.The cell phenotype and reactive oxygen species(ROS) were assayed by flow cytometry.IL-12p70 secreted in culture medium was detected by ELISA.Results The expression of CDllc、CD54、CD83、CD80 and CD86 was lower in immaturer DCs group than in mature DCs group.There is no expression of P-or E-selectin in immature and mature gurops.The expression of L-selectin was higher in immature group than in mature group.CD209/DC-SIGN was expressed significantly in both groups.The secretion of ROS was lower in mature group than in immature group.The secretion of IL-12p70 was higher in mature group than in immature group.MLR suggested that mature group had more potency to activate allogenic T cell proliferation.Conclusion The study of differentiation and maturity of cultured human dendritic cells has great value to exploring how to regulate DCs in immunological diseases." @default.
- W2378629724 created "2016-06-24" @default.
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- W2378629724 date "2006-01-01" @default.
- W2378629724 modified "2023-09-23" @default.
- W2378629724 title "The Character of Differentiation and Maturity of Cultured Human Dendritic Cells" @default.
- W2378629724 hasPublicationYear "2006" @default.
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