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- W2378632113 abstract "Objective To analyze the expression of T lymphocyte activation antigen in peripheral blood of aged patients with non-small cell lung cancer . Methods The lymphocytes from peripheral blood in 45 aged patients with non-small cell lung cancer were immunologically labeled in double fluorescence and CD3-FITC, CD25/HLA-DR and CD69-PE and determined by flow cytometry. Normal aged donors, young patiens with lung cancer and aged benign lesion group were used as controls. Results Peripheral blood CD3 +/CD25 +, CD3 +/HLA -DR + and CD3 +/CD69 + in T lymphocyte with 45 aged lung cancer(7.24±1.85,28.46±5.39 and 7.78±2.63, respectively) were significantly lower than those in normal aged controls(10.35±2.54,37.16±5.51,11.02±2.18, respectively)and aged benign lesion (9.53±3.02, 35.33±5.23, 10.67±2.45, respectively)( P 0.01). The expression of them in aged lung cancer patients was also lower than those in young lung cancer patients ( P 0.05 or P 0.01). There was no significantly statistic differences between normal aged controls and aged benign lesion ( P 0.05). Significant differences were found among them in stages Ⅲ, Ⅳ(7.15±1.13, 25.32±5.23, 7.14±2.81, respectively) and stagesⅠ,Ⅱ(8.06±1.21, 30.27±6.05, 8.43±2.67, respectively)( P 0.01). The expression of them in moderately differentiated cancer groups(8.23±1.23, 34.05±6.61 and 11.25±3.22, respectively)were significantly higher than those in poorly differentiated groups(7.02±1.35, 25.31±5.87, 5.31±3.57, respectively) ( P 0.01 ). The expression of them were not correlated with the pathological types( P 0.05). Conclusions Detection of CD3 +/CD25 +, CD3 +/HLA -DR + and CD3 +/CD69 + levels by flow cytometry might be helpful for reflecting the human immune function and the prognosis evaluation in patients with aged non-small cell lung cancer." @default.
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- W2378632113 date "2003-01-01" @default.
- W2378632113 modified "2023-09-22" @default.
- W2378632113 title "Clinical study on the expression of lymphocyte activation antigen in peripheral blood of aged patients with non-small cell lung cancer" @default.
- W2378632113 hasPublicationYear "2003" @default.
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