Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378633597> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2378633597 abstract "Current regulatory hurdles, the withdrawal of several drugs due to safety concerns, modest weight-loss efficacy using existing drugs and the lack of reimbursement in the US has resulted in limited investment in research and development of anti-obesity drugs by pharmaceutical companies. This has resulted in a limited range of treatment strategies for obese patients. The recent registration of lorcaserin (a 5-HT2C receptor agonist) and Qsymia (a combination of phentermine and topiramate), and the progression of the late-stage drugs liraglutide and NB32 may provide the backdrop for reinvestment to occur. Unlike many other therapeutic areas, preclinical models of obesity have a high degree of predictive validity for efficacy in the clinic and are of value in the discovery of novel compounds and their progression from research into the clinic. Although clinical trials for obesity drugs are of long duration with large patient cohorts required, recruitment is not an issue and end-points e.g. BMI are straightforward to measure. The emergence of new weight-loss agents that also treat diabetes, a co-morbidity associated with obesity, may provide improved treatment strategies. Importantly, even limited success of such drugs is likely to stimulate a marked increase in research and development as obesity is showing no sign of decline." @default.
- W2378633597 created "2016-06-24" @default.
- W2378633597 creator A5017418327 @default.
- W2378633597 creator A5018284364 @default.
- W2378633597 creator A5048050514 @default.
- W2378633597 date "2015-01-01" @default.
- W2378633597 modified "2023-09-27" @default.
- W2378633597 title "Chapter 6. New Drug Design and Therapeutic Development for Weight Reduction: Preclinical Studies and Clinical Trials" @default.
- W2378633597 doi "https://doi.org/10.1039/9781782622390-00090" @default.
- W2378633597 hasPublicationYear "2015" @default.
- W2378633597 type Work @default.
- W2378633597 sameAs 2378633597 @default.
- W2378633597 citedByCount "0" @default.
- W2378633597 crossrefType "book-chapter" @default.
- W2378633597 hasAuthorship W2378633597A5017418327 @default.
- W2378633597 hasAuthorship W2378633597A5018284364 @default.
- W2378633597 hasAuthorship W2378633597A5048050514 @default.
- W2378633597 hasConcept C126322002 @default.
- W2378633597 hasConcept C134018914 @default.
- W2378633597 hasConcept C160735492 @default.
- W2378633597 hasConcept C162324750 @default.
- W2378633597 hasConcept C177713679 @default.
- W2378633597 hasConcept C2777180221 @default.
- W2378633597 hasConcept C2778456266 @default.
- W2378633597 hasConcept C2779703844 @default.
- W2378633597 hasConcept C2780035454 @default.
- W2378633597 hasConcept C2781308992 @default.
- W2378633597 hasConcept C50522688 @default.
- W2378633597 hasConcept C511355011 @default.
- W2378633597 hasConcept C535046627 @default.
- W2378633597 hasConcept C544821477 @default.
- W2378633597 hasConcept C555293320 @default.
- W2378633597 hasConcept C64903051 @default.
- W2378633597 hasConcept C71924100 @default.
- W2378633597 hasConcept C98274493 @default.
- W2378633597 hasConceptScore W2378633597C126322002 @default.
- W2378633597 hasConceptScore W2378633597C134018914 @default.
- W2378633597 hasConceptScore W2378633597C160735492 @default.
- W2378633597 hasConceptScore W2378633597C162324750 @default.
- W2378633597 hasConceptScore W2378633597C177713679 @default.
- W2378633597 hasConceptScore W2378633597C2777180221 @default.
- W2378633597 hasConceptScore W2378633597C2778456266 @default.
- W2378633597 hasConceptScore W2378633597C2779703844 @default.
- W2378633597 hasConceptScore W2378633597C2780035454 @default.
- W2378633597 hasConceptScore W2378633597C2781308992 @default.
- W2378633597 hasConceptScore W2378633597C50522688 @default.
- W2378633597 hasConceptScore W2378633597C511355011 @default.
- W2378633597 hasConceptScore W2378633597C535046627 @default.
- W2378633597 hasConceptScore W2378633597C544821477 @default.
- W2378633597 hasConceptScore W2378633597C555293320 @default.
- W2378633597 hasConceptScore W2378633597C64903051 @default.
- W2378633597 hasConceptScore W2378633597C71924100 @default.
- W2378633597 hasConceptScore W2378633597C98274493 @default.
- W2378633597 hasLocation W23786335971 @default.
- W2378633597 hasOpenAccess W2378633597 @default.
- W2378633597 hasPrimaryLocation W23786335971 @default.
- W2378633597 hasRelatedWork W1627339726 @default.
- W2378633597 hasRelatedWork W1979525070 @default.
- W2378633597 hasRelatedWork W2025133490 @default.
- W2378633597 hasRelatedWork W2039592796 @default.
- W2378633597 hasRelatedWork W2062854249 @default.
- W2378633597 hasRelatedWork W2072095708 @default.
- W2378633597 hasRelatedWork W2077071563 @default.
- W2378633597 hasRelatedWork W2083508088 @default.
- W2378633597 hasRelatedWork W2096892863 @default.
- W2378633597 hasRelatedWork W2100027072 @default.
- W2378633597 hasRelatedWork W2135201954 @default.
- W2378633597 hasRelatedWork W2184675469 @default.
- W2378633597 hasRelatedWork W2214090396 @default.
- W2378633597 hasRelatedWork W2341657789 @default.
- W2378633597 hasRelatedWork W2418462861 @default.
- W2378633597 hasRelatedWork W2754824139 @default.
- W2378633597 hasRelatedWork W2902446313 @default.
- W2378633597 hasRelatedWork W2971839297 @default.
- W2378633597 hasRelatedWork W935990923 @default.
- W2378633597 hasRelatedWork W2559878735 @default.
- W2378633597 isParatext "false" @default.
- W2378633597 isRetracted "false" @default.
- W2378633597 magId "2378633597" @default.
- W2378633597 workType "book-chapter" @default.