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- W2378634771 abstract "Objective:Our previous result showed unravel the functional status of DC in the tissue of gastric cancer (GC) and precancerous lesions, and probed into the possibility of preventing solid carcinoma such as GC.Methods:In the experiment of immunotherapy for the tumor-bearing mice,treated by DC sensitized by mRNA of gastric acncer cells.Results:The indices such as the production rate of ascites of mice(75%),the metastasis rate of tumor(25%),the survival rate of animals (75%) and the average weight of trmor(2.04±0.33 g)showed that the condition of the mice treated by DC was better than that in the control group(P0.01).And the level of gene expression of IL-12, IFNγ and IL-18 in local tumor tissue was signficantly raised (P0.01) and the amount of local CD4 +?CD8 + cells was increased (P0.05) and the cytotoxicity of TIL was remarkably enhanced. After immunotherapy of the tumor-bearing mice by using exosomes from DC transfected with mRNA isolated from murine tumor cells, the indices are as good as sensitized DC's.However, DC transfected with mRNA isolated from mouse tumor cells may be effectively control the growth of tumor and ameliorate the symptoms,showing a certain therapeutic efficiency for mice carrying tumor can be realized.Conclusion:DC-derived exosomes sensitized by RNA of gastric carcinoma cells can ont only intensify the local immunologic function of GC but also make a better survival quality of the tumor-bearing host.Being a new type of therapeutic vaccine,exosomes is an important investigative value and a prospect of development." @default.
- W2378634771 created "2016-06-24" @default.
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- W2378634771 date "2003-01-01" @default.
- W2378634771 modified "2023-09-25" @default.
- W2378634771 title "A preliminary study of the immunotherapy of dendritic cells transfected with mRNA of gastric cancer cells in carried-tumor mice and its exosomes" @default.
- W2378634771 hasPublicationYear "2003" @default.
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