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- W2378635704 abstract "Objective To explore the structure basis of analgesic effect of interferon alpha(IFN α). Methods By using site directed mutagenesis, the structure of IFN α was reformed and a series of mutants of IFN α were obtained. The antiviral activity and opioid like activity of the IFN α mutants were tested. Results It was found that although the antiviral activity of IFN α decreased to 34 1% after the 122nd Tyr residue was changed to Ser, the analgesic activity of this mutant almost lost completely. Conclusions It was suggested that the analgesic domain locates around the 122nd Tyr residue of human IFN α molecule in tertiary structure and further indicated that there exists a distinct independent domain in IFN α molecule mediating analgesic activity respectively." @default.
- W2378635704 created "2016-06-24" @default.
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- W2378635704 date "2003-01-01" @default.
- W2378635704 modified "2023-09-23" @default.
- W2378635704 title "Analgesic Domain of Interferon-α" @default.
- W2378635704 hasPublicationYear "2003" @default.
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