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- W2378637959 abstract "Objectvie: Explorer the function of p38,NF-?B and IL-6 in pathogenesis of sarcopenia and it`s exercise-induced improvement.Methods: 24 male SD rats were divided into 3 groups: C group(quiet young group),S group(40 day D-Glactose injection-induced senecence),E group(40 days D-Glactose injection-induced senecence +6weeks exercise on treadmill).It detected the body weight,gastrocnemius weight,Phospho-p38,p38,Phospho-p65,p65,IL-6 mRNA,MRFs(MyoD,MyoG,Myf-5,MRF4)mRNA.Results: There was lower ratio of gastrocnemius weight to body weight,Phospho-p65,IL-6 mRNA,higher Phospho-p38,MyoD mRNA,MyoG mRNA,Myf-5 mRNA in S group than C group.There was higher ratio of gastrocnemius weight to body weight,Phospho-p38,Phospho-p65,IL-6 mRNA,MyoD mRNA,MyoG mRNA,MRF4 mRNA in E group than S group.There is lower or higher ratio of MyoD mRNA to MyoG mRNA in S group than C group or than E group.No change of p38 or p65 in S or E group compared with C group.Conclutions: NF-кB and IL-6 meditated but p38,MyoD,MyoG,Myf-5 resisted sarcopenia which may be meditated by NF-кB,IL-6 and resisted by p38/ MyoD,MyoG,Myf-5;p38,NF-кB,IL-6,MyoD,MyoG,MRF4 contributed to exercise-induced improvement of sarcopenia which may be meditated by p38,NF-кB,IL-6(or p38/NF-кB/IL-6)/ MyoD,MyoG,MRF4;Senescence induced fast to slow type transformation in skeletal muscle and the transformation was inhibited by exercise.Both p38 and p65 are insensitive to senescence and exercise." @default.
- W2378637959 created "2016-06-24" @default.
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- W2378637959 date "2012-01-01" @default.
- W2378637959 modified "2023-09-25" @default.
- W2378637959 title "Effect of p38,NF-кB and IL-6 on pathogenesis of sarcopenia and it's exercise-induced improvement" @default.
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