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- W2378638377 abstract "Objective To explore the application of PCR-denaturing high performance liquid chromatography(PCR/DHPLC) in detecting mutations of A1555G of mitochondrial 12S rRNA gene.Methods DNA samples were collected from four cases with clinically diagnosed congenital deafness caused by aminoglycoside antibiotics and 40 healthy individuals as control.The mutation of A1555G of mitochondrial 12S rRNA gene was determined by DHPLC,PCR-RFLP and DNA sequencing.Results The mutation of A1555G of mitochondrial 12S rRNA gene was found in the four patients but not in the 40 healthy individuals by both DHPLC and PCR-RFLP.The mutation of A1555G was then confirmed by DNA sequencing.DHPLC analysis showed distinctive mixed mutant doublet in 4 deaf patients and singlet in 40 healthy individuals respectively.Conclusions DHPLC technique may provide efficient,sensitive and cost-saving method for detecting mitochondrial DNA A1555G mutation in survey for large population." @default.
- W2378638377 created "2016-06-24" @default.
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- W2378638377 date "2011-01-01" @default.
- W2378638377 modified "2023-09-22" @default.
- W2378638377 title "Application of DHPLC for detecting mutation of mitochondrial DNA A1555G" @default.
- W2378638377 hasPublicationYear "2011" @default.
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