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- W2378638546 abstract "OBJECTIVE To investigate the feasibility of deliverying drug regionally to the inner ear using dexamethasome in situ gel,and provide scientific information for treating deafness.METHODS DSP(dexamethasone sodium phosphate)-loaded thermosensitive in situ gel was prepared by using poloxamer 407 as material.A HPLC method was established for the determination of DSP and dexamethasone(Dex). The pharmaceutical properties of DSP gel,such as lower critical solution temperature(LCST),DSP stability and release in vitro,were esti- mated.The pharmacokineties of DSP-loaded gel and solution were studied after an intratympanic or intravenous administration by determining the concentration of Dex in perilymph.RESULTS DSP-loaded gel had good stability,and its LCST was 26.5℃.The in vitro release kinet- ics was well characterized by Higuchi equation.The pharmacokinetic results showed that the perilymph AUC of intratympanic injection(it) DSP-loaded gel was 492.8-fold higher than that of iv DSP solution.Moreover,DSP-loaded gel following it extended the MRT by 5 times or compared with the solution.CONCLUSION Thermnsensitive in situ gel is a promising inner ear-oriented drug delivery system." @default.
- W2378638546 created "2016-06-24" @default.
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- W2378638546 date "2006-01-01" @default.
- W2378638546 modified "2023-09-25" @default.
- W2378638546 title "Study on Dexamethasone Thermosensistivie in Situ Gel for Treating Deafness" @default.
- W2378638546 hasPublicationYear "2006" @default.
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