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- W2378639173 abstract "Objective To observe the protection of soybean isoflavone and folacin to kidney in rat model of homocysteine(HCY) diabetes.Methods 32 male Kunming mice were divided into four groups randomly,which included normal control group(NS),homocysteine diabetes group(HCYDM),soybean isoflavone group(SIF),soybean isoflavone and folacin group(SIFFA).HCY diabetes models were made by vena caudalis injection of streptozocin and intraperitoneal injection of HCY.SIF group and SIFFA group were interfered by injection of soybean isoflavone and folacin.Results Compared with NS group,the weight of kidney increased(P0.01),the weight of rat decreased(P0.05),kidney/body value increased(P0.01),the area of glomerulus cell and caryon enlarged significantly and the absorbance of TGF-β increased(P0.01) in HCYDM group(P0.05).Compared with HCYDM group,the weight of kidney,kidney/body value,the area of glomerulus cell,the area of caryon and the absorbance of TGF-β all decreased in SIF group(P0.05) and SIFFA group(P0.01).Compared with SIF group,the area of glomerulus cell decreased significantly.The area of caryon and the absorbance of TGF-β decreased slightly.There was significant statistical significance in decreasing blood sugar chronically(after 8 weeks treatment)in SIFFA group and SIF group.Conclusion Soybean isoflavone and folic acid working as preserve factors of cell can resist the occurrence of diabetic nephropathy." @default.
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- W2378639173 date "2007-01-01" @default.
- W2378639173 modified "2023-09-28" @default.
- W2378639173 title "Protection of soybean isoflavone and folacin to kidney in rats of homocysteine diabetes model" @default.
- W2378639173 hasPublicationYear "2007" @default.
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