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- W2378639343 abstract "Objective To investigate the pathological changes after radiation in rectal cancers. Methods 25 patients with advanced carcinoma of the rectum underwent preoperative radiation (40 Gy) followed by complete surgical resection of the tumor with total rectal excision. The time interval between completion of radiation and surgical resection was 28 days. Pathology slides with HE stain and TUNEL or PCNA stains partly were reviewed. The expression and distribution of necrosis, mitosis and apoptosis were observed in the radiation group (n =25) and non -radiation group (n = 25) of rectal cancers. Results Of the 25 rectal cancers in radiation group, 8(32% ) , 5(20% ) and 2(8% ) cases showed necrosis (++) , (+ ++) and (+ + + + ) , respectively, higher than that in the non - radiation group ( P 0. 001). However, There were no statistical differences in necrosis(+) , mitosis and apoptosis between the radiation group and the non - radiation group ( P 0. 05 ). Conclusion Necrosis of rectal cancer cells is the most direct pathological changes after radiotherapy. Evaluation of pathological changes rectal cancers after radiation may be useful in treatment of advanced cancer." @default.
- W2378639343 created "2016-06-24" @default.
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- W2378639343 date "2003-01-01" @default.
- W2378639343 modified "2023-09-22" @default.
- W2378639343 title "Pathological Changes after Radiation in Rectal Cancers" @default.
- W2378639343 hasPublicationYear "2003" @default.
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