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- W2378639551 abstract "Objective To investigate the effects of high thoracic epidural blockade (TEB) on cardiac function and plasma fibrinogen (FIB) level in patients with dilated cardiomyopathy (DCM).Methods Thirty patients with DCM (NYHAⅢorⅨ) of both sexes (22 males,8 females) aged 26-70 yrs were randomly divided into 2 groups (n=15 each):TEB group and control group.In TEB group epidural catheter was inserted through T_(3-4) or T_(4-5) interspace and advanced 3-4 cm into epidural space cephalad.0.5% hdocaine 3-5 ml was injected through the catheter into epidural space every 2 h for 4 weeks in addition to routine medical treatment.In control group the patients received only routine medical treatment.Blood samples were then taken for determination of plasma FIB concentration using micro-capillary assay.Doppler echocardiography was performed before and after the treatment.Results The two groups were comparable with respect to age,M/F ratio and cardiac function.Cardiac function was significantly improved after treatment in TEB group as compared to control group.The left ventricular end-diastolic diameter (LVEDD) was significantly reduced and left ventricular ejection fraction (LVEF) was significantly increased after 4 week treatment in TEB group,while there was no significant difference in LVEDD and LVEF before and after treatment in control group.Plasma FIB concentration was significantly decreased after treatment in TEB group while in control group there was no significant change in plasma FIB concentration after treatment.Conclusion High TEB combined with routine medical treatment can improve cardiac function and decrease plasma FIB concentration." @default.
- W2378639551 created "2016-06-24" @default.
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- W2378639551 date "2006-01-01" @default.
- W2378639551 modified "2023-09-23" @default.
- W2378639551 title "Effects of high thoracic epidural blockade on plasma fibrinogen in patients with dilated cardiomyopathy" @default.
- W2378639551 hasPublicationYear "2006" @default.
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