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- W2378639797 abstract "Objective The models of B lymphoma in abdominal cavity of SCID mouse were established for exploring the diagnosis as well as therapy strategies.Methods Human Namalwa cell lines(7.5×106)were transplanted into abdominal cavity of CB-17severe combined immunodeficiency(SCID)mouse with 4-5weeks.The presentation of tumor onset and the survival time of SCID mouse were observed.The tumor tissue was detected by H-E staining and immunohistochemistry with CD20,CD79a,Ki-67and CD3.Results The median onset time was(18.67±1.94)days,which exits enlarged tumors in abdominal cavity of SCID mouse,which presented erected hair,cachexia and tardiness.The median survival time was(28.00±6.36)days.The liver,kidney,stomach,pancreas,spleen,lung,organs of cavitas pelvis,muscle and skin were infiltrated by a number of Namalwa cells.Immunohistochemical positive staining showed diffuse CD79aand Ki-67,focal CD20,whereas CD3was negative.Conclusion The human B lymophma model of SCID mouse can be successfully established with Namalwa cell lines,which is an important and useful tool for lymphoma." @default.
- W2378639797 created "2016-06-24" @default.
- W2378639797 creator A5085797790 @default.
- W2378639797 date "2013-01-01" @default.
- W2378639797 modified "2023-09-22" @default.
- W2378639797 title "Establishment of models of human B lymphoma in abdominal cavity of SCID mouse" @default.
- W2378639797 hasPublicationYear "2013" @default.
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