Matches in SemOpenAlex for { <https://semopenalex.org/work/W2378645509> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2378645509 abstract "Objective To study the effect of recombinant mutant human tumor necrosis factor(rmhTNF-NC) and doxorubicin(DOX)on inhibition of proliferation and apoptosis in Raji cells.Methods Raji cells cultured in vitro were divided into control group,rmhTNF-NC group,DOX group and rmhTNF-NC+ DOX group.Inhibition of proliferation of Raji cel1s was evaluated by methyl thiazolyl tetrazolium(MTT) assays and apoptosis was assessed by flow cytometry.Results Treated with different concentrations(0,100,500,1 000,5 000,10 000 U / mL) of rmhTNF-NC for 24,48,72 h had no significant effect on proliferation inhibition rate and apoptosis rate of Raji cells(P0.05).Proliferation inhibition rate and apoptosis rate were significantly higher in Raji cells treated with 1 μg/mL DOX combined with 10 000 U/mL rmhTNF-NC than those treated with DOX or rmhTNF-NC alone for 24 and 48 h(P0.05).Proliferation inhibition rate of Raji cells treated with 2 μg/mL DOX combined with 10 000 U/mL rmhTNF-NC was also significantly higher than those treated with DOX or rmhTNF-NC alone for 24 and 48 h(P0.05).However,no significant difference was seen in apoptosis rate between Raji cells treated with 2 μg/mL DOX combined with 10 000 U/mL rmhTNF-NC and those treated with DOX alone(P0.05),yet cell death rate was significantly higher(P0.05).Proliferation inhibition rate and apoptosis rate increased with the increase of time treated(P0.05).Conclusions Combination of rmhTNF-NC with DOX had a synergistic effect and could increase proliferation inhibition rate,induce apoptosis,and promote cell death." @default.
- W2378645509 created "2016-06-24" @default.
- W2378645509 creator A5010167248 @default.
- W2378645509 date "2011-01-01" @default.
- W2378645509 modified "2023-09-24" @default.
- W2378645509 title "Effect of recombinant mutant human tumor necrosis factor and doxorubicin on inhibition of proliferation and apoptosis of Raji cells" @default.
- W2378645509 hasPublicationYear "2011" @default.
- W2378645509 type Work @default.
- W2378645509 sameAs 2378645509 @default.
- W2378645509 citedByCount "0" @default.
- W2378645509 crossrefType "journal-article" @default.
- W2378645509 hasAuthorship W2378645509A5010167248 @default.
- W2378645509 hasConcept C126322002 @default.
- W2378645509 hasConcept C153911025 @default.
- W2378645509 hasConcept C16232356 @default.
- W2378645509 hasConcept C17991360 @default.
- W2378645509 hasConcept C185592680 @default.
- W2378645509 hasConcept C190283241 @default.
- W2378645509 hasConcept C202751555 @default.
- W2378645509 hasConcept C203014093 @default.
- W2378645509 hasConcept C2776694085 @default.
- W2378645509 hasConcept C2779707156 @default.
- W2378645509 hasConcept C2780783641 @default.
- W2378645509 hasConcept C2781303535 @default.
- W2378645509 hasConcept C553184892 @default.
- W2378645509 hasConcept C55493867 @default.
- W2378645509 hasConcept C62112901 @default.
- W2378645509 hasConcept C71924100 @default.
- W2378645509 hasConcept C86803240 @default.
- W2378645509 hasConceptScore W2378645509C126322002 @default.
- W2378645509 hasConceptScore W2378645509C153911025 @default.
- W2378645509 hasConceptScore W2378645509C16232356 @default.
- W2378645509 hasConceptScore W2378645509C17991360 @default.
- W2378645509 hasConceptScore W2378645509C185592680 @default.
- W2378645509 hasConceptScore W2378645509C190283241 @default.
- W2378645509 hasConceptScore W2378645509C202751555 @default.
- W2378645509 hasConceptScore W2378645509C203014093 @default.
- W2378645509 hasConceptScore W2378645509C2776694085 @default.
- W2378645509 hasConceptScore W2378645509C2779707156 @default.
- W2378645509 hasConceptScore W2378645509C2780783641 @default.
- W2378645509 hasConceptScore W2378645509C2781303535 @default.
- W2378645509 hasConceptScore W2378645509C553184892 @default.
- W2378645509 hasConceptScore W2378645509C55493867 @default.
- W2378645509 hasConceptScore W2378645509C62112901 @default.
- W2378645509 hasConceptScore W2378645509C71924100 @default.
- W2378645509 hasConceptScore W2378645509C86803240 @default.
- W2378645509 hasLocation W23786455091 @default.
- W2378645509 hasOpenAccess W2378645509 @default.
- W2378645509 hasPrimaryLocation W23786455091 @default.
- W2378645509 hasRelatedWork W2354296778 @default.
- W2378645509 hasRelatedWork W2354395054 @default.
- W2378645509 hasRelatedWork W2358950307 @default.
- W2378645509 hasRelatedWork W2372228045 @default.
- W2378645509 hasRelatedWork W2375266103 @default.
- W2378645509 hasRelatedWork W2378536668 @default.
- W2378645509 hasRelatedWork W2380458387 @default.
- W2378645509 hasRelatedWork W2380960353 @default.
- W2378645509 hasRelatedWork W2381938181 @default.
- W2378645509 hasRelatedWork W2384552372 @default.
- W2378645509 hasRelatedWork W2386361724 @default.
- W2378645509 hasRelatedWork W2386562069 @default.
- W2378645509 hasRelatedWork W2387885238 @default.
- W2378645509 hasRelatedWork W2414442306 @default.
- W2378645509 hasRelatedWork W2526862088 @default.
- W2378645509 hasRelatedWork W2751172265 @default.
- W2378645509 hasRelatedWork W3028737262 @default.
- W2378645509 hasRelatedWork W3116362728 @default.
- W2378645509 hasRelatedWork W3198923575 @default.
- W2378645509 hasRelatedWork W1765925496 @default.
- W2378645509 isParatext "false" @default.
- W2378645509 isRetracted "false" @default.
- W2378645509 magId "2378645509" @default.
- W2378645509 workType "article" @default.