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- W2378654315 abstract "Keratinocyte growth factor 2(KGF-2) is a member of the FGF family that is mainly synthesized by mesenchymal cells and acts predominantly on epithelial cells in a paracrine manner.It is known to play an important role in fetal limb and lung development;skin wound healing and prostatic epithelial cell growth.The KGF-2 coding sequence were isolated from human kidney cDNA library, revealing that the Kgf-2 gene is also expressed in the kidney apparatus.Purified from prokaryotic E.coli cells, the effects of the recombinant KGF-2 protein in cultured keratinocyte were analyzed by using MTT assay and in situ TUNEL assay.Interestingly, results revealed that KGF-2 promoted keratinocyte cell growth by stimulating cell proliferation and attenuating cell apoptosis.These findings supported a few evidences that KGF-2 could contribute to alveolar epithelial cells against apoptosis.Cell migration assays for the first time revealed that KGF-2 could stimulate keratinocyte cell migration in vitro.In addition, in the pilot animal test, recombinant KGF-2 incorporated within the hydrogel dressing exhibited significantly stimulatory effect on cutaneous wound healing.These combined effects implicate a potential therapeutic application of human recombinant KGF-2 in the future." @default.
- W2378654315 created "2016-06-24" @default.
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- W2378654315 date "2009-01-01" @default.
- W2378654315 modified "2023-09-25" @default.
- W2378654315 title "Effects of Keratinocyte Growth Factor 2(KGF-2) on Keratinocyte Growth,Migration and on Excisional Wound Healing" @default.
- W2378654315 hasPublicationYear "2009" @default.
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