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- W2378660421 abstract "Objective: To synthesize(5-fluorouracil-1-acetic acid)-4′-curcuminate and investigate its anti-tumor effect.Methods: 5-Fluorouracil(5-FU) reacted to chloroacetic acid in the alkaline environment to prepare 5-fluorouracil-1-acetic acid(3),then compound 3 was esterified by reacting to curcumin to prepare(5-fluorouracil-1-acetic acid)-4′-curcuminate(4).Cell proliferation was assayed by MTT method to explore the cytotoxic effect of compound 4 on HL60,K562,SGC7901 and SW480 cells in vitro.The tumor model in mice was established by inoculation of H22 cells.At 8 days after intraperitoneal injection of compound 4,mice were killed,and the subcutaneous sarcoma were isolated and weighted.Results: The IC50 of(5-fluorouracil-1-acetic acid)-4′-curcuminate calculated by the inhibition rates were 5.774,11.05,17.83 and 13.67 μg·mL-1 in HL60,K562,SGC7901 and SW480 cells,respectively.Compound 4 at doses of 80,160,320 mg·kg-1 significantly inhibited tumor growth by 26.85%,30.65% and 61.37%,respectively,as compared with control group.Conclusion:(5-Fluorouracil-1-acetic acid)-4′-curcuminate synthesized in this study shows an obvious anti-tumor effect in vivo and in vitro." @default.
- W2378660421 created "2016-06-24" @default.
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- W2378660421 date "2011-01-01" @default.
- W2378660421 modified "2023-09-24" @default.
- W2378660421 title "Synthesis and anti-tumor effect of(5-fluorouracil-1-acetic acid)-4′-curcuminate" @default.
- W2378660421 hasPublicationYear "2011" @default.
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