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- W2378664726 abstract "Objective: To investigate the effect of 8-B-cAMP on The expression of protein kinase A(PKA) and Growth associated protein-43 (GAP-43). Methods: The focal cerebral ischemia and reperfusion model was induced by nylon monofilamem in rats. Forty five rats were randomly assigned to sham operated (control)group, cerebral ischemia- reperfusion only group and 8-B-cAMP group (intra-cerebroventricular inject 8-B-cAMP). The contents of cAMP in cerebral cortex of rats was detected by radio immunoassay (RIA) and the change of PKA and GAP-43 protein expression was determined by Western blot technique. Results: The contents of cAMP and the expression level of PKA and GAP-43 protein decreased at 6h and 24h after cerebral ischemia- reperfusion. 8-B-cAMP elevated the expression level of GAP-43 protein and increased the contents of cAMP and activated PKA. There is a coincidence between the change of GAP-43 and cAMP-PKA. Conclusion: 8-B-cAMP can increase the expression level of GAP-43 and PKA protein and improve axon regeneration." @default.
- W2378664726 created "2016-06-24" @default.
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- W2378664726 date "2007-01-01" @default.
- W2378664726 modified "2023-09-23" @default.
- W2378664726 title "The expression of Growth associated protein-43 and protein kinase A increased by intra-cerebroventricular administration of 8-B-cAMP in rats with focal cerebral ischemia and reperfusion" @default.
- W2378664726 hasPublicationYear "2007" @default.
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