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- W2378664942 abstract "Objective To establish osteoporosis models in ovariectomized(OVX) and dexamethasoned(Dex) SD rats,in order to understand OVX and Dex' influence on bone metabolism.Exploring at different time points,the distinction of bone mineral density(BMD) and serologic between the two models.Methods Six months pure line female rats were chosen and were administrated i.m Dex.And the other rats were subjected to excise bilateal OVX.So that the two different osteoporosis models of rats were established.At different time points,the change of serum calcium,phosphorus,alkaline phosphatase(ALP),BMD and bone structure between them was compared.Results The bone histomorphology of rats in OVX group and Dex group presented typical osteoporosis.At every time point,BMD was both lower than that in the control group(P0.05 or P0.01).At different time points the ALP level obtained from two models was both higher(P0.01) The serum calcium and phosphorus in OVX group were in the normal range(P0.05),serum calcium was lower(P0.05) and phosphorus was higer(P0.05) in Dex group.Conclusion The OVX group and Dex group have some distinctions in serology index and bone morphometry at different time points.Meanwhile we found that the succeed time of OVX model can advance to 10 weeks and the succeed time of Dex group should be 5 weeks or even longer." @default.
- W2378664942 created "2016-06-24" @default.
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- W2378664942 date "2008-01-01" @default.
- W2378664942 modified "2023-09-25" @default.
- W2378664942 title "The Analysis of Bone Mineral Density and Serum Index between Osteoporosis Models in Ovariectomized and Hormone" @default.
- W2378664942 hasPublicationYear "2008" @default.
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