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- W2378689095 abstract "Objective To measure the urinary 8-isoprostaglandin F_(2a)(8-isoPGF_(2a))and in vitro oxidized low density lipoprotein(ox-LDL) lag time in patients with amyotrophic lateral sclerosis (ALS).Methods Nineteen ALS patients served as an ALS group according to the EL Escorial diagnosis criteria,and 19 age- and influence factors-matched healthy subjects served as a control group in this study.Their in vitro ox-LDL lag time and urinary 8-isoPGF_(2a) level were measured by copper oxidation-conjugated diene assay and ELISA,respectively.Results No significant difference was found in urinary 8-isoPGF_(2a) level between ALS group and control group although it was higher in ALS group than in control group(48.28±4.78 vs 47.25±2.32 ng/mmol creatinine, P 0.05).The in vitro ox-LDL lag time was shorter in ALS group than in control group (59.32±8.65 vs 83.16±8.37 min,P0.01).Conclusion Elevated LDL oxidative stress and reduced 8-isoPGF_(2a) antioxidant ability play a certain role in pathogenesis of ALS,suggesting that effective antioxidant therapy is of certain clinical significance in controlling progression of ALS and improving its prognosis." @default.
- W2378689095 created "2016-06-24" @default.
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- W2378689095 date "2012-01-01" @default.
- W2378689095 modified "2023-09-28" @default.
- W2378689095 title "Quantitative assay of oxidative stress in patients with amyotrophic lateral sclerosis" @default.
- W2378689095 hasPublicationYear "2012" @default.
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