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- W2378699118 abstract "To observe the effect of methionine enkephalin(MENK) on the maturation and expression of Toll like receptor 4(TLR-4) of DCs derived from murine bone marrow progenitors(BM-DCs)induced by GM-CSF and to investigate the regulatory mechanism of MENK on the immmune fuction of DCs,the BM-DCs were prepared and cultured in vitro in the presence of GM-CSF,or MENK alone or in combination of the two factors.The mRNA of TLR-4 was detected by RT-PCR and the protein of TLR-4 was detected by Western-blot technique after seven day's culture.Phenotypic features of BM-DCs were analyzed by FACS,the immune function was assayed by means of mixed lymphocyte reaction(MLR).The results indicate that the expressions of TLR-4 and costimulatory molecules of DC cultured in the midium contained both MENK and GM-CSF were significantly increased compared to those from the normal control group(P0.01) and GM-CSF group(P0.05),and these DC had strong ability to trigger MLR These findings suggest that MENK may promote the maturation and expressions of TLR-4 at both mRNA and protein levels,and enhance immunologic functions of BM-DCs." @default.
- W2378699118 created "2016-06-24" @default.
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- W2378699118 date "2013-01-01" @default.
- W2378699118 modified "2023-09-25" @default.
- W2378699118 title "Synergy between methionine enkephalin and GM-CSF in the induction of bone marrow-derived dandritic cells" @default.
- W2378699118 hasPublicationYear "2013" @default.
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