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- W2378699647 abstract "Objective To investigate the expression of p-AKT and PTEN and the suppressive effect of EGCG on the proliferation and apoptosis of human uterine leiomyoma cells in vitro.Methods The proliferation of cells was detected by MTT methods.The distribution of cell cycle and the rate of apoptosis were determined by flow cytometry.The expression of p-AKT and PTEN protein was detected by immunocytochemistry.The statistical analysis of the results was performed with t text and analysis of variance.Results EGCG could inhibit the proliferation of uterine leiomyoma cells in vitro as direct relation of concentrations and times(P0.05),enhance the apoptosis rate in the doseage-dependent and down-regulate the expression of p-AKT protein and up-regulate the expression of PTEN protein(P0.05).Conclusion EGCG could inhibit proliferation and induce apoptosis in human uterine leiomyoma cells in vitro by down-regulating the expression of p-AKT protein and up-regulating the expression of PTEN protein." @default.
- W2378699647 created "2016-06-24" @default.
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- W2378699647 date "2011-01-01" @default.
- W2378699647 modified "2023-09-24" @default.
- W2378699647 title "Effect of EGCG on the proliferation and apoptosis of human uterine leiomyoma cells in vitro" @default.
- W2378699647 hasPublicationYear "2011" @default.
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