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- W2378727465 abstract "AIM: To study nitric oxide-induced early preconditioning of cardiac myocytes and its signal transduction pathways. METHODS: Cultured neonatal rat cardiac myocytes were pretreated with SNAP and L-Arg respectively for 1 h. The injury of cardiac myocytes was detected after subsequent 6 h hypoxia to determine whether NO could induce early preconditioning. Cells were incubated with cGMP inhibitor methylene blue, protein kinase C(PKC) inhibitor D-sphingosine, calcium antagonist lacidipine and adenosine triphosphate sensitive potassium channel [K(ATP)channel] blocker glibenclamide respectively for half an hour. Cells were then treated with SNAP for 1 h. Cardiac myocytes injury was observed by detecting cell viability and lactate dehydrogenase (LDH). RESULTS: Both SNAP and L-Arg could induce early preconditioning of cardiac myocytes, nitric oxide synthase (NOS) inhibitor L-NAME block the protective effect of L-Arg, Methylene blue could completely abolish SNAP-induced cardioprotection, and D-sphingosine, lacidipine and glibenclamide weaken SNAP-induced protection. CONCLUSION: NO can induce early preconditioning protection of cardiac myocytes via cGMP-dependent pathway. Activation of PKC and opening of calcium channels and K(ATP)channels may be important downstream events of cGMP." @default.
- W2378727465 created "2016-06-24" @default.
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- W2378727465 date "2004-01-01" @default.
- W2378727465 modified "2023-09-22" @default.
- W2378727465 title "Nitric oxide-induced early preconditioning of cardiac myocytes and its signal transduction pathways" @default.
- W2378727465 hasPublicationYear "2004" @default.
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