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- W2378744541 abstract "Objective To investigate the expression of TLR2 and TLR4in breast cancer and its clinical significance.Methods Employing RT-PCR,the expression of TLR2 and TLR4in breast cancer and paraneoplastic tissue of 213 patients with breast cancer were detected and the association of the expression with clinicopathology was analyzed. Results The positive rate of expression of TLR2 and TLR4mRNA in breast cancer tissue was higher than its corresponding paraneoplastic tissue(χ2=32.10,144.57;P0.01).The expression of TLR2 and TLR4in the cancer tissue was associated with its histological grade,positive expression of estrogen receptor(ER)and progesterone receptor(PR)(χ2=4.06-30.86,P0.05),the expression of TLR2 was also related to the expression of p53gene(χ2=5.71,P0.05). Conclusion The high expression of TLR2 and TLR4in breast cancer tissue is likely to play an important role in the occurrence and development of this malignancy." @default.
- W2378744541 created "2016-06-24" @default.
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- W2378744541 date "2014-01-01" @default.
- W2378744541 modified "2023-09-28" @default.
- W2378744541 title "EXPRESSION OF TLR2 AND TLR4 IN BREAST CANCER AND ITS CLINICAL SIGNIFICANCE" @default.
- W2378744541 hasPublicationYear "2014" @default.
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