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- W2378763669 abstract "To study the secondary metabolites and their antitumor activity of the marine fungus Aspergillus sydowii MNP12010103,column chromatography on macroporous resin,silica gel,Sephadex-LH20,PHPLC were used to isolate the compounds from the marine fungus MNP12010103 using bioactivity guide method. The structures of these compounds were identified by spectroscopic analysis. Seven compounds obtained were identified as cyclo-( Leu-Pro)( compound 1),1,8-dihydroxy anthraquinone( compound 2),indole-5-carboxaldehyde( compound 3),physcion( compound 4),5α-cholestane-3-one( compound 5),uracil( compound 6),and thymidine( compound 7). Compound 5 was isolated from microorganism for the first time,compound 2 from marine fungus for the first time,and compound 1,3,4 from the fungi of Aspergillus sydowii for the first time. Compounds 2exhibits inhibitory activities on PANC-1 with IC50of 45. 47 μg /mL and compounds 4 shows cytotoxicity against PC-3 with IC50of 53. 97 μg /mL. The DPPH radical scavenging rate of both compound 2and compound 4 are more than 50% at a concentration of 100 μg /mL." @default.
- W2378763669 created "2016-06-24" @default.
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- W2378763669 date "2014-01-01" @default.
- W2378763669 modified "2023-09-28" @default.
- W2378763669 title "Study on metabolites from marine fungi Aspergillus sydowii" @default.
- W2378763669 hasPublicationYear "2014" @default.
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