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- W2378771007 abstract "Objective To explore effect of L-Arginine (L-Arg) on the oxygen free radicals and antioxidant enzymes in kidneys, ce rebra and testis of diabetic rats. Methods The diabetes mellitus ( DM) rats model made by injection of alloxan were randomly divided into DM group, L-Arg group and control group. After 4 weeks, the rats were killed to detect the activities of NOS, SOD, GSH-Px and the contents of NO and MDA in kidneys, cerebra and testis tissues. Results NOS activities in testis (P 0. 01) , contents of NO in cerebra and testis (P 0. 05, P 0. 01), SOD activities in kidneys, GSH-Px activities in kidneys, cerebra and testis ( P 0. 01, P 0. 001, P 0.05) of DM groups were significantly lower than those of normal controls, but MDA contents in kidneys, cerebra and testis were significantly higher than those of normal controls ( P 0.001). L-Arg increased significantly NOS activities and NO contents (P0.001) in kidneys, cerebra and testis, SOD activities in cerebra (P 0.01) and GSH-Px acitivities in cerebra and testis ( P 0. 05 , P 0. 001) ; decreased significantly MDA contents in kidneys, cerebra and testis (P 0. 01, P 0.001, P 0.001). Conclusion Lipids peroxidation injury could be found in kidneys, cerebra and testis of DM rats; L-Arg could protect antioxidase activities through increasing NO contents, which could play some alleviative roles in oxygen stress of kidneys, cerebra and testis in DM rats." @default.
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- W2378771007 title "Effect of L-Arginine on the oxygen free radicals and antioxidant enzymes in kidneys, cerebra and testis of diabetic rats" @default.
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