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- W2378800510 abstract "Objective: To investigate the expression of the deleted in colorectal cancer(DCC) gene in pancreatic cancer and evaluate its relationship with the clinicopathologic factors.Methods:The pancreatic cancer tissue microarray was constructed and the expression of DCC protein was examined in pancreatic cancer and their paired normal pancreatic tissues by immunohistochemistry.The relationship between DCC protein expression and clinicopathological features such as tumor size,differentiation degree,lymph node metastasis,and TNM stages were analyzed.Results:Immunohistochemical results of pancreatic cancer tissue microarray showed that the positive rate of DCC expression in pancreatic cancer was 17%(7/41),significantly lower than that in normal pancreatic tissues 87%(34/39)(P0.001).The expression level of DCC in pancreatic cancer with lymph node metastasis was significantly lower than that without lymph node metastasis [(0.29±0.768) vs(1.27±2.27),P=0.037].The expression levels of DCC were significantly lower in stage Ⅲ and Ⅳ pancreatic cancer tissues than that in stage Ⅰand stage Ⅱ pancreatic cancer tissues [(0.25±0.71) vs(1.39±2.63) and(1.25±2.12),P=0.032].Conclusion: The less of declined or deleted DCC protein expression in pancreatic cancer occurrs in the oncogenesis and development of pancreatic cancer.The less expression of DCC protein detected by immunohistochemistry might play an important role in evaluation of the prognosis of pancreatic cancer." @default.
- W2378800510 created "2016-06-24" @default.
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- W2378800510 date "2007-01-01" @default.
- W2378800510 modified "2023-09-23" @default.
- W2378800510 title "The expression of DCC detected by pancreatic cancer tissue microarray in pancreatic cancer and its clinical significance" @default.
- W2378800510 hasPublicationYear "2007" @default.
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