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- W2378812321 abstract "To observe the pacemaker role of interstitial cells of Cajal (ICC) on relaxation of the gastric smooth muscle and the effect of secretin on it. Isolated muscle segments of pacemaker area of upper 1/3 gastric corpus and antral circular muscle layers of rats were immersed in homoeothermic perfusion Krebs solution. Signals were input into the amplifier of RM6000 polygraph through transducers and contractile activity of muscle layers were recorded. The effect of selective lesion of ICC by methylene blue and intense illumination. The results are as follow: (1) Gastric muscle layers with ICC have stable contractile activity. The frequency and amplitude of contractile activity of antrum are higher than that of pacemaker. (2) After selective lesioning of ICC, contractile amplitude and frequency of pacemaker and antrum are significantly decreased. The contraction almost disappeared. (3) Secretin 0.06～0.5mg/L decrease markedly and dose-dependently the amplitude and frequency of contractile waves of pacemaker and antrum. The inhibitory effect of secretin on gastric smooth muscle contractile activity were almost completely abolished after selective lesioning of ICC. Anti-secretin serum and atropine also block the effect of secretin." @default.
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- W2378812321 date "2003-01-01" @default.
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- W2378812321 title "Impact of secretin on gastric smooth muscle relaxation mediated by interstitial cells of Cajal in rats" @default.
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