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- W2378826493 abstract "Objective To analyze the autoimmune status of kidney in transgenic mice with high serum titer of anti-keratin autoantibody(AK auto Ab).Methods AK auto-Ab transgenie mice were set-up with conventional procedures,and the mice older than 20 weeks were selected for study.Urinary protein was quan- tified by Bradford method,and SDS-PAGE electrophoresis was used to analyze the type of proteinuria.Speci- mens of kidney were subjected to HE and PAS stain and immunofluorescence analysis and electrum microscopy observation were also performed.Results Compared with littcrmates,transgenie mice showed higher urinary proteins level(P0.05),mainly with mixed proteinuria.Electron microscopy revealed mesangial proliferative glomerulonephritis,and IgM was found to deposit in the glomeruli(++～+++).Conclusion AK auto Ab trans- genic mice are prone to develop autoimmune disease and autoantibody deposition in kidney may be an impor- tant reason for the pathogenesis." @default.
- W2378826493 created "2016-06-24" @default.
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- W2378826493 date "2007-01-01" @default.
- W2378826493 modified "2023-09-28" @default.
- W2378826493 title "Nephritic changes of transgenic mice with high serum titer of anti-keratin autoantibody" @default.
- W2378826493 hasPublicationYear "2007" @default.
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