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- W2378839669 abstract "Aim:To explore the brain function improvement of application of exogenous erythropoietin(EPO) in hypoxic ischemic brain damage(HIBD) rats.Methods: 45 Sprague-Dawley rats(7-day old) were randomly divided into sham operation group,EPO treatment group,HIBD group(each group n=15).There were no ligations of carotid artery(CA) and hypoxia but only isolation of CA in sham operation group.EPO 5 000 IU/Kg was injected into abdomen immediately in EPO treatment group after making HIBD model.Physiological saline was injected into abdomen in HIBD group at same time.The histological changes(HE staining) and the brainstem auditory evoked potential(BAEP) were observed.Results: HIBD group represented atrophy,local hemorrhage of modeling side hemisphere.Histopathological changes included neuron necrosis,vacuolization,etc.,but these were much slighter in EPO treatment group.There were no significant difference(except V wave in 28,35 days rats and III wave in 21 days rats) of peak latency(PL) of BAEP in EPO treatment group and sham control group.There were significant reduce(P0.05) of PL in EPO treatment group compared HIBD group after 21 days(except I,V wave).There were significant longer of interpeak latency(IPL) in HIBD group compared with sham operation group(P0.05) and EPO treatment group(P0.05) after 21 days.Conclusion:Exogenous EPO treatment can significantly improve brain function and developmental situation in rats with HIBD." @default.
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- W2378839669 date "2011-01-01" @default.
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- W2378839669 title "Protection of erythropoietin in neonatal rats with hypoxic-ischemic brain damage" @default.
- W2378839669 hasPublicationYear "2011" @default.
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