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- W2378841099 abstract "Purpose To study immune tolerance induced by immature dendritic cells transfusion and bone marrow transplantation in rat renal transplantation model,and to explore a possible strategy for renal allograft protection in clinic. Methods Immature dendritic cells (imDC) and fresh bone marrow cells (BMC) from DA rat were prepared for use before transplantation. Renal allograft from DA rat was transplanted to Lewis rat. Forty recipient rats were randomly divided into 5 groups: (1) negative group; (2) imDC group; (3) BMT group; (4) imDC+ BMT group; (5) cyclophosphamide (CP) group. Anti-donor cytotoxic T lymphocyte activity was assayed by 51Cr release test. Cytokine in the supernatant of splenic cells culture were measured by ELISA,including IL-4,IFN-γ and TGF-β. Results The median survival time (MST) was (7.12±1.25) days in negative group,(24.36±3.20) days in imDC group, (7.87±2.10) days in BMT group,(18.13±2.16) days in Cp group. When combined imDC transfusion and BMT,the MST was prolonged to (80.75±16.88) days, which had significant difference compared with negative group, imDC group,BMT group and CP group (P0.01).CTL from tolerant rats had decreased cytotoxicity to cells from donor rats (4.3±1.0)% vs (39.6±4.4)%,P0.01),but showed normal cytotoxicity to cell from the third party rat (9.8±3.2) %.IFN-γ in the supernatant of tolerant rat splenic cells culture was (532.78±34.54) ng/L,which was lower than normal and rejection rat (P0.01). IL-4 and TGF-β in the supernatant of tolerant rat splenic cells culture was (185.44±32.17) ng/L and (716.82±197.62) ng/L, which was higher than normal or rejection rat (P0. 01). Conclusions Combined used of imDC transfusion and bone marrow transplantation is an effective way to induce immune tolerance in rat renal transplantation model. Its possible mechanisms may due to immune deviation of cytokine net and rat donor-specific CTL anergy." @default.
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- W2378841099 date "2005-01-01" @default.
- W2378841099 modified "2023-09-27" @default.
- W2378841099 title "Immune Tolerance Induced by Immature Dendritic Cells and Bone Marrow Transplantation in Rat Renal Allogeneic Graft Model and Its Mechanisms" @default.
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