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- W2378848133 abstract "Objective To explore the correlations of serum PC cell-derived growth factor(PCDGF),vascular endothelial growth factor(VEGF) and thymidine kinase1(TK1) levels with clinical pathological parameters in lung cancer,and their combined value in the diagnosis of lung cancer. Methods Serum PCDGF and VEGF levels were detected by ELISA,and serum TK1 level by chemiluminescence enzyme immunoassay in 123 patients with lung cancer,60 patients with benign lung disease and 61 healthy controls. Results The levels of serum PCDGF,VEGF and TK1 in the patients with lung cancer were 18. 27(6. 24,58. 86) ng /mL,1 072. 73(272. 42,2 686. 46) ng /mL and 1. 59(0. 21,8. 21) pmol /L,respectively,and were significantly higher than those with benign lung disease and the healthy controls( Z = 81. 349,85. 769 and 18. 818,respectively,P 0. 05). Serum PCDGH level was significantly related to tumor staging and lymph node metastasis(Z = 8. 063 and 2. 488,P 0. 05),while VEGF level related to different histological types of lung cancer(Z = 6. 634,P 0. 05). There was no any statistical correlation between serum PCDGF and VEGF levels(r = 0. 017,P =0. 786). The sensitivity of PCDGF was 83. 7% for the diagnosis of lung cancer,and when PCDGF,VEGF and TK1 were combined,the sensitivity increased to 95. 9%. The specificity of TK1 was 90. 7%,which was the highest among the three markers. The accuracy of all the three markers was low. Conclusion The levels of serum PCDGF,VEGF and TK1 significantly increased in the patients with lung cancer. PCDGF was associated with lung cancer staging and lymph node metastasis,which may be used as a potential marker for the diagnosis of lung cancer and the malignant evaluation." @default.
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- W2378848133 date "2014-01-01" @default.
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- W2378848133 title "Detection of serum PC cell-derived growth factor,vascular endothelial growth factor and thymidine kinase 1 levels and its clinical significance in the patients with lung cancer" @default.
- W2378848133 hasPublicationYear "2014" @default.
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