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- W2378848203 abstract "Objective To study the influences of mesenchymal stem cells derived from human umbilical cord blood(HUCB-MSCs) on allogeneic peripheral blood T lymphocytes.Methods HUCB-MSCs were isolated from normal human umbilical cord blood,isolated and cultured in vitro,and then surface marker was examined with FCM.After isolating CD3+T cells from normal human peripheral blood,CD3+T cells were mixed with HUCB-MSCs stimulated with PHA or not.Five days later,the effects of HUCB-MSCs on T-cell proliferation was detected by 3H-TdR.Cytokines production of PHA-stimulated T cells in co-culture was measured with ELISA.T-cell apoptosis affected by HUCB-MSCs were also observed by FCM.Results HUCB-MSCs showed a spindle-shaped fibroblastic morphology in culture.The populations appeared as a homogenous population and were uniformly positive for the expression of CD29,CD44,and HLA-ABC,but negative for the expression of CD14,CD34,CD45,and HLA-DR.In co-culture,MSCs significantly suppressed PHA-stimulated T-cell proliferation(5 230±550 vs 10 500±800 counts/min,P0.001).Both pro-inflammatory cytokines IFN-γ(510±60 vs 1 580±100 pg/mL,P0.001)and TNF-α(590±20 vs 1 180±30 pg/mL,P0.001)secreted by T cells were inhibited by HUCB-MSCs while anti-inflammatory cytokines IL-10(105±5 vs 17±2 pg/mL,P0.001)and IL-4(16.3±8.2 vs 4.1±1.8 pg/mL,P0.001) were up-regulated.In addition,MSCs-inhibited T cells were not apoptotic during 5 days' culture.Conclusions HUCB-MSCs may inhibit the activity of allogeneic peripheral blood T lymphocytes." @default.
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- W2378848203 date "2011-01-01" @default.
- W2378848203 modified "2023-09-23" @default.
- W2378848203 title "Mesenchymal stem cells derived from human umbilical cord blood inhibit the allogeneic peripheral blood T lymphocytes" @default.
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