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- W2378848764 abstract "Objective To investigate lead-induced changes of synaptic structure in hippocampal CA_1 area,and the antagonistic effects of zinc.Methods Wistar rats were exposed to lead or lead-zine crom dirinking 6.15 mmol/L lead acetate solution or the solution containing 3.10 mmol/L zinc sulphate respectively,for 40 days.Serum and hippocampal lead content in rats were measured with atomic absorption method;The changes of subcellular structure of hippocampal CA_1 area were studied with transmission electron microscope and morphometry method.Results Compared with the control and lead-zinc group,the serum and hippocampal lead content of lead-exposed rat was significantly increased (P0.05);the number of the rough endoplasmic reticulum and mitochondria were decreased,there were a lot of vacuoles in them; the synaptic ratio of synapse containing over 50 vesiculae was decreased (P0.01),while the constituent ratio of synapse containing less the 10 vesiculae was increased (P0.01);the membrane area of the presynapses and postsynapses were significantly decreased (P0.01),but no significant changes were found between the cntrol and lead-zinc groups.Conclusion The effects of lead on the changes of subcellular structure in hippcompal CA_1 area,zinc might play an important role in preventing lead-induced damages." @default.
- W2378848764 created "2016-06-24" @default.
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- W2378848764 date "2005-01-01" @default.
- W2378848764 modified "2023-09-24" @default.
- W2378848764 title "Protectve effects of zinc on lead-induced damage on subcellular structure and synaptic parameter in hippocampus" @default.
- W2378848764 hasPublicationYear "2005" @default.
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