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- W2378855985 abstract "Objective:To explore the effects and the mechanism of endostar on proliferation and apoptosis of the human umbilical vein endothelial cells(HUVECs)induced by renal cell carcinoma(ACHN cell lines)supernatant fluid.Methods: To detect the effects of endostar on the proliferation of the HUVECs by MTT;detect the effects of endostar on the apoptosis of the HUVECs by Annexin V-FITC binding assay;detect the effects of endostar on the expression of Cbl-b,c-Cbl,p-Akt and p-ERK by western blot.Results: Endostar inhibited the proliferation of HUVECs induced by renal cell carcinoma supernatant fluid,promoteed the apoptosis of HUVECs reduced the expression of Cbl-b,c-Cbl,p-Akt and p-ERK in HUVECs,and the effects were depended on the concentration of endostar.Conclusion: Endostar inhibits the proliferation,promotes the apoptosis of HUVECs induced by renal cell carcinoma supernatant fluid,and ubiquitin ligases pathway,p-Akt pathway or p-ERK pathway may be the molecular mechanism of endostar." @default.
- W2378855985 created "2016-06-24" @default.
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- W2378855985 date "2011-01-01" @default.
- W2378855985 modified "2023-09-28" @default.
- W2378855985 title "Effects and preliminary study on the mechanism of endostar on proliferation and apoptosis of the HUVECs induced by tumor supernatant fluid" @default.
- W2378855985 hasPublicationYear "2011" @default.
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