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- W2378857788 abstract "Objective: To study the inl uence and mechanism of four active components combination of astragalus and ginsenoside, such as astragaloside, ginsenoside Rg1, Rb1, and notoginseng R1 on the active substance to against oxidative stress in the early stage of cerebral ischemia-reperfusion with mice. Methods: C57BL/6 mice were randomly assigned, and proceeded intragastric administration for 3 days continuously. Cerebral ischemia-reperfusion model was established after 1 hour at the late administration. Brain tissue homogenate was made to detect the contents of glutathione(GSH), total antioxidant capacity(T-AOC) and the activity of total superoxide dismutase(T-SOD). Results: After cerebral ischemia-reperfusion, T-AOC ability, T-SOD activity and GSH content in brain tissue were decreased significantly. T-SOD activity was increased significantly bycompatibility of four active component, compatibility of astragaloside Ⅳ and ginsenoside Rg1 and compatibility of astragaloside Ⅳ and ginsenoside Rb1. GSH contents were increased significantly by in astragaloside Ⅳ, compatibility of four active component, compatibility of astragaloside Ⅳ and ginsenoside Rg1, compatibility of astragaloside Ⅳ and ginsenoside Rb1 and compatibility of astragaloside Ⅳ and notoginsenoside R1. T-AOC capacity was increased significantly by ginsenoside Rg1, notoginsenoside R1, compatibility of four active component, compatibility of astragaloside Ⅳ and ginsenoside Rg1, compatibility of astragaloside Ⅳ and ginsenoside Rb1, compatibility of astragaloside Ⅳ and notoginsenoside R1. Compare with compatibility of astragaloside Ⅳ and ginsenoside Rg1, compatibility of astragaloside Ⅳ and ginsenoside Rb1 and compatibility of astragaloside Ⅳ and notoginsenoside R1 alone, the increased effect on GSH of ginsenoside Rg1, Rb1 and notoginsenoside R1 alone was less, and the increased effect on T-AOC of astragaloside Ⅳ and ginsenoside Rb1 alone was less. Compare with compatibility of four active component, the active of T-SOD was less with ginsenoside Rg1, Rb1 and notoginsenoside R1, the contents of GSH were less with astragaloside Ⅳ, ginsenoside Rg1, Rb1, notoginsenoside R1 and compatibility of astragaloside Ⅳ and notoginsenoside R1, and the capacity of T-AOC was less with astragaloside Ⅳ and ginsenoside Rb1. Conclusion: Compatibility of astragaloside Ⅳ, ginsenoside Rg1, Rb1 and notoginsenoside R1 could increase T-AOC ability, T-SOD activity and GSH content significantly, and could enhance the effects on the scavenging of oxygen free radicals and the resistance of oxidative stress injury after cerebral ischemia-reperfusion in mice. Furthermore, the effects on T-SOD activity mainly came from four active components combination, the effect on GSH mainly played by astragaloside Ⅳ, the effect on T-AOC mainly played by ginsenoside Rg1 and notoginsenoside R1." @default.
- W2378857788 created "2016-06-24" @default.
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- W2378857788 date "2014-01-01" @default.
- W2378857788 modified "2023-09-26" @default.
- W2378857788 title "Influence of compatibility of four active components of astragalus and notoginseng on the active substances of anti-oxidative stress in the early stage of cerebral ischemiareperfusion of mice" @default.
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