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- W2378862014 abstract "Objective To investigate the effects of Porphyromonas gingivalis on the expression of MMP-1 and TIMP-1 in human periodontal ligament fibroblasts through using an in vitro model.Methods MMP-1 and TIMP-1 protein levels in culture supernatant were determined by ELISA at the different time intervals(6 h,12 h,24 h,48 h) following continuous co-culture of P.gingivalis W83 and ATCC33277 with HPDLFs.The ratio of MMP-1 /TIMP-1 was calculated.Results The expression of MMP-1 and TIMP-1 was enhanced in HPDLFs infected with P.gingivalis;the ratio of MMP-1/TIMP-1 in infected HPDLFs was significantly higher than that of control group(P 0.05).The ratio of MMP-1/TIMP-1 in HPDLFs infected with P.gingivalis W83 was significantly higher than that in HPDLFs infected with P.gingivalis ATCC33277(P 0.05).Conclusion P.gingivalis can accelerate secretion of MMP-1 and TIMP-1 in HPDLFs,which causes periodontal tissue destruction.P.gingivalis W83 has stronger pathogenicity for periodontal disease by producing extracellular matrix in local." @default.
- W2378862014 created "2016-06-24" @default.
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- W2378862014 date "2012-01-01" @default.
- W2378862014 modified "2023-09-24" @default.
- W2378862014 title "Effect of Porphyromonas gingivalis on the expression of MMP-1 and TIMP-1 in human periodontal ligament fibroblasts" @default.
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