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- W2378878502 abstract "To investigate the inducing apoptotic effect of Tetrahydro-iso-humulone(TH) on SGC-7901 cells via the mitochondrial pathway.SGC-7901 cells are treated with 2,8,32 μg/mL of TH for 72 hours.The MTT assay is used to detect the effect of TH on SGC-7901 cells in vitro.Fluorescence microscope is used to observe the morphological changes of SGC-7901 cells.Flow cytometry is employed to analyse the apoptotic rates.Activity test kit is used to investigate the activity changes of Caspase-9.Western Blot assay is employed to detect the expression of Caspase-3 protein.TH could inhibit the proliferation of SGC-7901 cells in a dose-dependent and time-dependent manner.Apoptotic rates of SGC-7901 cells increased after treated with different dosages of TH,and the activity of Caspase-9 in SGC-7901 is increased by TH in a dose-dependent manner.TH could also up-regulate the expression of Caspase-3 protein in SGC-7901 cells in a dose-dependent manner.TH can inhibit the proliferation of SGC-7901 cells,and inducing cell apoptosis via the mitochondrial pathway may be one of the important action mechanisms of TH." @default.
- W2378878502 created "2016-06-24" @default.
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- W2378878502 date "2009-01-01" @default.
- W2378878502 modified "2023-09-23" @default.
- W2378878502 title "Study on cell apoptosis effect induced by tetrahydro-iso-humulone on human gastric cancer SGC-7901 cells via mitochondrial pathway" @default.
- W2378878502 hasPublicationYear "2009" @default.
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