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- W2378879244 abstract "AIM: To study the effect of Yupingfeng Powder(YPFP) on rat's allergic rhinitis induced by stimulating ovalbumin.and reveal the influence on Th1,Th2 and Th1/Th2 proportion. METHODS: 8-week-old BALB/c mice were sensitized by means of intranasal and systemic intraperitoneal injection application of OVA,6 subjects were administered including 2,500 mg/kg extracts of YPFP for 7 days in early stage(interference group);6 mice were administered YPFP in after challenge(therapy group);the placebo group were given saline.After 7 days,Th1 and Th2 in splenocyte were detected by flow cytometry(FCM) and nasobuccal mucosa pathology were observed. RESULTS: When compared with Th2 of animal model group(9.86±1.40),there was a significant decrease expressing Th2 after PFP treatment(3.41±0.72,P0.01),but interference group was also significant protection(against) the OVA-induced Th2 early response(6.27±1.21,P0.05),This study could demonstrate that YPFP inhibited Th2-induced upper airway inflammation(F=30.53,P0.0001). CONCLUSION: The present study provides a first insight into YPFP might therapeutically affect Th2 dominant airway inflammation,clearly indicating that YPFP can elevate ratio of Th1/Th2 and suppress expression of Th2." @default.
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- W2378879244 date "2006-01-01" @default.
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- W2378879244 title "Effects of Yupingfeng Powder on Th1/Th2 balanace in murine model of allergic rhinitis" @default.
- W2378879244 hasPublicationYear "2006" @default.
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