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- W2378884209 abstract "Objective To investigate the pathophysiological mechanism of proliferation and apoptosis of spermatogenic cell in idiopathic oligospermia.Methods Thirty-nine patients with oligospermia were included in the trail.Cell blocks of seminal fluid were made and were observed under light microscope.Expression of PCNA and P16,incidence of apoptosis in spermatogenic cells were detected by immunohistochemistry and in situ 3′DNA end labeling technique.fifteen seminal fluids which were proved to be normal examination served as controls.Results proliferation index(16.6±13.1)% in tests of patients was lower than the normal controls(35.1±5.7)%,P0.001.Expression of P16(17.4±8.9)% and apoptosis index(1.9±1.1)% in tests of patients were higher than the normal controls(6.2±2.1)% and(0.3±0.1)%,respectively,bothP0.01.Conclusion The present study indicated that one of the main causes of oligospermia results from lower proliferation and higher apoptosis of spermatogenic cell,which are related to abnormal expression of P16.It may be a useful indicator for monitoring patient with idiopathic oligospermia." @default.
- W2378884209 created "2016-06-24" @default.
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- W2378884209 date "2009-01-01" @default.
- W2378884209 modified "2023-09-23" @default.
- W2378884209 title "Study on changes of proliferation and apoptosis of spermatogenic cell in idiopathic oligospermia" @default.
- W2378884209 hasPublicationYear "2009" @default.
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