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- W2378885103 abstract "Objective To investigate the loss of heterozygosity(LOH) on chromosome loci 3p,10q and the infection of HPV and also to analyze the relationship between them and clinicopathological characteristics in cervical carcinoma.Methods Fifty-two invasive cancers,33 CIN and 12 normal cervical tissues were examined through the LOH and HPV infection analysis with 6 polymorphic microsatellite markers.Results The LOH occurred in 52 invasive cancers was obviously higher than that in CIN and normal cervical tissues,P0.01.The LOH at 3p was higher than the LOH at 10q,P0.05.The LOH in stage Ⅲ and Ⅳ was obviously higher than that in stage Ⅰ and Ⅱ,P0.05.As to the incidence of the LOH,it is higher in squamous cell carcinoma at chromosome 3p,but higher in adenocarcinoma at chromosome 10q and there was no difference among the high,moderate and poor differetiated.The rate of infection of HPV in invasive cancer was obvious higher than that in CIN and in normal cervical tissue,P0.05,and the incidence of LOH in 3p was higher in HPV(+) than that in HPV (-) ,P0.05.Conclusions The putative suppressor genes are likely to be located on specific chromosome region of 3p and 10q.The co-operation of infection and LOH at 3p has more significance in the development of cervical carcinoma." @default.
- W2378885103 created "2016-06-24" @default.
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- W2378885103 date "2003-01-01" @default.
- W2378885103 modified "2023-09-23" @default.
- W2378885103 title "Analysis of LOH of Chromosome and HPV Infection in Human Cervical Carcinoma" @default.
- W2378885103 hasPublicationYear "2003" @default.
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