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- W2378889156 abstract "Objective To study relationship between GSTM1 and GSTT1 gene polymorphism with hepatotoxicity caused by antitubercular drugs.Methods One hundred and twenty-four pulmonary tuberculosis patients with onisoniazid,rifampicin and pyraznamide who developed hepatotoxicity using defined criteria were prospectively identified.The 25 cases with non-hepatotoxicity is as control group,the patients with hepatotodxicity are 99.Genotyping for GSTM1 and GSTT1 was performed by multiplex PCR on genomic DNA.Results GSTMI null and GSTTI null in hepatic lesion suggested significant difference between them by Partial(P0.01).Conclusion GSTM1 null or GSTT1 null do appear to be associated with ATD induced hepatoxicity in Chinese population.Statistically significant associations were found between polymorphism of GSTM1 or GSTT1 with ATD-induced hepatotoxicity." @default.
- W2378889156 created "2016-06-24" @default.
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- W2378889156 date "2013-01-01" @default.
- W2378889156 modified "2023-09-23" @default.
- W2378889156 title "Relationship between GSTM1 and GSTT1 gene polymorphism with hepatotoxicity caused by antitubercular drugs" @default.
- W2378889156 hasPublicationYear "2013" @default.
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