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- W2378889585 abstract "Objective To investigate the clinical significance of changes of serum levels IL-17 and sICAM-1 in patients with chronic obstructive pulmonary disease (COPD).Methods 30 patients with COPD during acute exacerbation and stable period, and 23 normal persons (control group) were chosen. In testing the pulmonary function, the ratio of eutrophils/ leukocytes Neu /Leu%, enzyme linked immunosorbent assay (ELISA) was used to measure IL-17 and sICAM-1 in all.Results The patients′plasma IL-17 concentration, sICAM-1 concentrations were significantly higher in the acute exacerbation of COPD than the stabilization period (P0.01,P0.01). Also the measures of plasma IL-17 concentration, sICAM-1 concentration was significantly higher in the acute exacerbation of COPD than the healthy control group (P0.01,P0.01). The patients' plasma IL-17 concentration, sICAM-1 concentration were significantly higher in the stable COPD than the control group (P0.01,P0.01). In the acute exacerbation, IL-17, sICAM-1 and Neu/Leu% was positively correlated (r=0.824,P0.01;r=0.827,P0.01).Conclusion The serum IL-17 and sICAM-1 levels increase in patients with COPD during the acute exacerbation and stable periods, which indicates that IL-17 and sICAM-1 play a role in the course of inflammatory reaction of air passage of COPD." @default.
- W2378889585 created "2016-06-24" @default.
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- W2378889585 date "2009-01-01" @default.
- W2378889585 modified "2023-09-28" @default.
- W2378889585 title "Study on changes of IL-17 and sICAM-1 in the serum of patients suffering from COPD and its clinical significance with airway inflammation" @default.
- W2378889585 hasPublicationYear "2009" @default.
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