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- W2378889731 abstract "Objective:To further explore the pathogenesis of kawasaki disease (KD).Methods:Calculating percentage of apoptotic cells and assaying DNA fragmentation in peripheral blood mononuclear cell(PBMC)stimulated by anti CD3 for 0,12,24,48,72 h in vitro from 30 patients with KD and 20 age matched health children.Results:Apoptotic cell percentage and DNA fragmentation were markedly decreased(P 0.001 ) and delayed (compared with those in normal controls),which could reach the states of control group only by 72 h cultured.Remarkabely increased production of IL 6 in cultured supernatants of PBMC induced by phytohemagglutinin(PHA) from KD patients was found in comparison with those of PBMC from controls(P0.001).Adding anti IL 6 mAb to the cultures or using intravenous immunoglobulin(IVIG)in vivo led to significantly decreased production of IL 6(P0.001),and reversed decreased apoptotic cell percentage and delayed DNA fragmentation to be compatible with normal controls.Conclusion:Over produced IL 6 might be involved in down regulation of peripheral blood lymphocyte apoptosis in KD." @default.
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- W2378889731 date "1999-01-01" @default.
- W2378889731 modified "2023-09-25" @default.
- W2378889731 title "Preliminary study on the decreased apoptosis of lymphocytes in acute kawasaki disease" @default.
- W2378889731 hasPublicationYear "1999" @default.
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