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- W2378903311 abstract "Objective: To investigate the correlation between immunophenotype and clinical features in patients with large granular lymphocyte leukemia(LGLL).Methods: Immunophenotypic profile and clinical data of 24 patients with LGLL were collected,and differences between T / NK subtype were compared.Results: T-specific antigen and most pan-T antigen were expressed in T-LGLL,but CD8+CD4-was the subtype.Aggressive T-LGLL showed loss of one or more pan-T antigens and the change of immunofluorescence intensity in T antigen.Pan-T antigen CD2,CD7 and NK associated antigen CD56 and/or CD11c were often expressed in NK-LGLL,but with no CD3 and CD5 expression,and the immunophenotypes presented no remarkable difference in NK-LGLL indolent and aggressive subtype.There was significant difference in the average age,WBC count,lymphocyte proportion,hemoglobin and B symptoms between indolent and aggressive T-LGLL (P0.05),and there was significant difference in the average age,hemoglobin,hepatosplenomegaly,lymphadenopathy and B symptoms between indolent and aggressive NK-LGLL(P0.05).Conclusions: Analysis of immunophenotype combined with clinical characteristics is helpful for the diagnosis of LGLL and T/NK subtype,and is helpful to determine its aggression or inertia." @default.
- W2378903311 created "2016-06-24" @default.
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- W2378903311 date "2010-01-01" @default.
- W2378903311 modified "2023-09-28" @default.
- W2378903311 title "Immunophenotypes and Clinical Features of 24 Cases With Large Granular Lymphocyte Leukemia" @default.
- W2378903311 hasPublicationYear "2010" @default.
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