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- W2378907080 abstract "Objective To investigate the effects and its possible mechanisms of cell division Cycle 42(Cdc42) on the apoptosis of vascular endothelial cells in ischemia / reperfusion(I / R) injury.Methods Human umbilical vein endothelial cells(HUVECS) were isolated and cultured and then subjected to the ischemia and reperfusion.Experimental groups: ①Control group;② I / R group;③liposome group;④AS group;⑤MS group;⑥SP600125 + AS group;⑦SP600125 group.The endothelial cells apoptosis ratio was detected with the TUNEL analysis.The expression of Cdc42,JNK,p-JNK,Bax and Bcl-2 were detected by western blot.Results The level of Cdc42,endothelial cells apoptosis ratio and phosphorylation of JNK increased but the ratio of Bcl-2 / Bax decreased in the I / R group as compared to the control group.The expression of Cdc42,endothelial cells apoptosis ratio and phosphorylation of JNK was lower in the AS group than those in I / R group,liposome group and MS group.The ratio of Bcl-2 / Bax was highest in these four groups.Conclusion Cdc42 can promote the endothelial cells apoptosis following ischemia / reperfusion.AS will down-regulate the expression of Cdc42 in ischemia / reperfusion(I / R) injury by inhibiting the phosphorylation of JNK and ratio of Bcl-2 / Bax." @default.
- W2378907080 created "2016-06-24" @default.
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- W2378907080 date "2013-01-01" @default.
- W2378907080 modified "2023-09-24" @default.
- W2378907080 title "Effects of Cdc42 on Apoptosis of Vascular Endothelial Cells in Ischemia /Reperfusion Injury and Mechanism" @default.
- W2378907080 hasPublicationYear "2013" @default.
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