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- W2378907573 abstract "【Objective】 To assume that the laterality of cervical lymph nodal metastases(CLNM) has an influence on prognosis for inoperable thoracic esophageal squamous cell carcinoma. 【Methods】 A total of 395 inoperable esophageal SCC patients receiving chemoradiotherapy were classified into five groups according to different disease stadium of metastasis: Group A, no evidence of regional lymph nodal disease; Group B, evidence of regional lymph nodal disease; Group C, evidence of unilateral cervical lymph node metastases(CLNM); Group D, evidence of bilateral CLNM; Group E, evidence of other metastatic diseases. The endpoints were overall survival(OS), progression-free survival(PFS). The prognostic factors were examined in the univariate and multivariate analysis. 【Results】 Three year OS of Group A, B, C, D, E were 47.6%, 46.4%, 33.5%; 14.8%, 5.7%(P= 0.000). On univariate analysis, sex, tumor location, length, T stage, M stage, chemotherapy regimen and disease stage were significantly associated with OS(P 0.05). Multivariate analysis demonstrated that sex, T stage, chemotherapy regimen and disease stage were prognostic factors on OS. 【Conclusion】 Compared to bilateral CLNM, unilateral CLNM is associated with longer OS in esophageal SCC and should be regarded as regional disease, especially, in SCCs of the upper and middle thirds of the esophagus. Female sex, earlier T stage,cisplatin plus docetaxel as part of concurrent chemoradiotherapy and unilateral cervical nodal lymph metastasis are independent predictors of survival in esophageal SCC." @default.
- W2378907573 created "2016-06-24" @default.
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- W2378907573 date "2014-01-01" @default.
- W2378907573 modified "2023-09-24" @default.
- W2378907573 title "Prognosis Analysis of Thoracic Esophageal Squamous Cell Carcinoma with/without Cervical Lymph Node Metastasis Treated with Concurrent chemotherapy" @default.
- W2378907573 hasPublicationYear "2014" @default.
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