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- W2378908059 abstract "Objective To compare the differences and similarities of the breast cancer stem cell makers,ALDH1+ and CD44+/CD24-,in gene subtypes and clinical correlated factors,and to investigate the distribution in gene subtypes of the two complementary markers and the clinical correlation.Methods Double-staining immunohistochemistry(IHC)and single-staining IHC were applied to test the overlapped expression of ALDH1+ and CD44+/CD24-phenotypes in cancer tissues of 203 breast cancer patients who had not received chemotherapy.Results 5% breast cancer patients showed overlapped expression of ALDH1+/CD44+/CD24-phenotype which was mainly found in HER-2 type(18%)and Triple negative type(45%),with a main pathological type of invasive ductal carcinoma,and the 2-year disease-free survival rate was lower than other phenotypes(P0.05).Conclusion Only a small part of the breast cancer patients were of ALDH1+/CD44+/ CD24-/low phenotype which mainly existed in Triple negative type,and the main pathological type was invasive ductal carcinoma,the 2-year disease-free survival rate was low.ALDH1+ and CD44+/CD24-may mark different levels of breast cancer stem cells,therefore,ALDH1+ and CD44+/CD24-detection by complementary immunohistochemical techniques may predict patient prognosis." @default.
- W2378908059 created "2016-06-24" @default.
- W2378908059 creator A5018747306 @default.
- W2378908059 date "2013-01-01" @default.
- W2378908059 modified "2023-09-25" @default.
- W2378908059 title "Overlapped Expression of ALDH1~+,CD44~+/CD24~- in Breast Cancer and Its Correlation with Gene Subtypes and Clinical Factors" @default.
- W2378908059 hasPublicationYear "2013" @default.
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