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- W2378909654 abstract "Objective To explore the role of ERK1/2 protein in development of myocardial hypertrophy.MethodsMyocardial cells were isolated from ventricles of 1～3-day-old neonate rats and purifed by a culture method.Neonate rat cardiomyocyte hypertrophic responses were assayed by measuring protein content,protein synthesis rate and cell surface area.Expression of protein ERK1/2 were detected by Western blot.Results Cell protein content,3H-leucine(3H-Leu) incorporation and cell surface area increased by treating of cardiomyocytes with T(10-10～10-6mol/L) for 24 h.The maxium effect was observed at the concentration of 10-8mol/L.The increase of cell protein content induced by T was inhibited by pretreating with flutamide(10-5mol/L) for 2 h,while there was no effect on cardiomyocytes pretreating with flutamide alone.The increase of 3H-Leu incorporation induced by T was blocked by PD98059(50 μmol/L).Expression of ERK1/2 was upregulated significantly by treating with testosterone for 24 h at the level of 10-8mol/L.The increased expression of ERK1/2 induced by T was reversed by pre-treating with flutamide(10-5mol/L) for 2 h.Conclusion T with physio-concentration may induce cardiomyocyte hypertrophy and this effect was possibly mediated through the activation of ERK1/2 signalling.During this procession,T upregulated the protein expression of ERK1/2 mediated by androgen receptor." @default.
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- W2378909654 date "2010-01-01" @default.
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- W2378909654 title "Testosterone induces cardiomyocyte hypertrophy in rats and upregulates the expression of ERK1/2" @default.
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